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A retrospective cohort study regarding the effect of sirolimus-based immunosuppression protocol on the long-term survival of hepatocellular carcinoma patients after liver transplantation / 中华外科杂志
Chinese Journal of Surgery ; (12): 245-248, 2014.
Artículo en Chino | WPRIM | ID: wpr-314718
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the influence of sirolimus on the long-term survival of patients after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>Clinic data of 165 consecutive patients who underwent OLT for HCC from February 2005 to March 2012 was analyzed retrospectively. Among them, 94 patients were treated with a sirolimus-based immunosuppressive protocol after OLT, while the other 71 patients with a FK506-based protocol. Postoperative survival time, survival, disease-free survival (DFS) and tumor recurrence rates between the two groups were compared.</p><p><b>RESULTS</b>The 2 groups were comparable in all clinicopathologic parameters. The sirolimus-based group had higher patient survival rates than the control group at 1-year (87% vs. 97%, P = 0.03), 2-year (80% vs. 88%), 3-year (76% vs. 85%) and 5-year (63% vs. 75%). The 1-year, 2-year, 3-year and 5-year recurrence rates were 12% vs. 3%, 17% vs. 9%, 21% vs. 9% (P = 0.04) and 31% vs. 16% (P = 0.03). Early and mid-HCC (I - II stage) of 131 cases (control group 61 cases, sirolimus-based group of 70 patients). The 1-year, 2-year, 3-year and 5-year survival rates were 90% vs. 97% , 80% vs. 90%, 78% vs. 86% and 65% vs. 82% (P = 0.04) and recurrence rates were 10% vs. 3%, 16% vs. 8%, 18% vs. 8% and 29% vs. 11% (P = 0.01).</p><p><b>CONCLUSION</b>The sirolimus-based immunosuppressive protocol reduce long-term postoperative recurrence rate and improve the survival rate of patients after OLT for HCC significantly (especially early-mid HCC).</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cirugía General / Tasa de Supervivencia / Estudios Retrospectivos / Mortalidad / Trasplante de Hígado / Tacrolimus / Carcinoma Hepatocelular / Sirolimus / Usos Terapéuticos / Quimioterapia Tipo de estudio: Estudio de etiología / Guía de Práctica Clínica / Estudio observacional / Estudio pronóstico Límite: Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Surgery Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cirugía General / Tasa de Supervivencia / Estudios Retrospectivos / Mortalidad / Trasplante de Hígado / Tacrolimus / Carcinoma Hepatocelular / Sirolimus / Usos Terapéuticos / Quimioterapia Tipo de estudio: Estudio de etiología / Guía de Práctica Clínica / Estudio observacional / Estudio pronóstico Límite: Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Surgery Año: 2014 Tipo del documento: Artículo