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Expression of Total Vascular Endothelial Growth Factor and the Anti-angiogenic VEGF 165 b Isoform in the Vitreous of Patients with Retinopathy of Prematurity / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2505-2509, 2015.
Artículo en Inglés | WPRIM | ID: wpr-315306
ABSTRACT
<p><b>BACKGROUND</b>This study was to examine the expression of total vascular endothelial growth factor (VEGF) and the anti-angiogenic VEGF 165 b isoform in the vitreous body of retinopathy of prematurity (ROP) patients, and to further study the role of the VEGF splicing in the development of ROP.</p><p><b>METHODS</b>This was a prospective clinical laboratory investigation study. All patients enrolled received standard ophthalmic examination with stage 4 ROP that required vitrectomy to collect the vitreous samples. The control samples were from congenital cataract patients. The expression of total VEGF and the anti-angiogenic VEGF 165 b were measured by enzyme-linked immunosorbent assay. Results were analyzed statistically using nonparametric tests.</p><p><b>RESULTS</b>The total VEGF level was markedly elevated in ROP samples while VEGF 165 b was markedly decreased compared to control group. The relative protein expression level of VEGF 165 b isoform was significantly decreased in ROP patients which were correlated with the ischemia-induced neovascularization.</p><p><b>CONCLUSIONS</b>There was a switch of VEGF splicing from anti-angiogenic to pro-angiogenic family in ROP patients. A specific inhibitor that more selectively targets VEGF 165 and controls the VEGF splicing between pro- and anti-angiogenic families might be a more effective therapy for ROP.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cuerpo Vítreo / Retinopatía de la Prematuridad / Recien Nacido Prematuro / Ensayo de Inmunoadsorción Enzimática / Estudios Prospectivos / Isoformas de Proteínas / Factor A de Crecimiento Endotelial Vascular / Metabolismo Tipo de estudio: Estudio observacional Límite: Femenino / Humanos / Masculino / Recién Nacido Idioma: Inglés Revista: Chinese Medical Journal Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cuerpo Vítreo / Retinopatía de la Prematuridad / Recien Nacido Prematuro / Ensayo de Inmunoadsorción Enzimática / Estudios Prospectivos / Isoformas de Proteínas / Factor A de Crecimiento Endotelial Vascular / Metabolismo Tipo de estudio: Estudio observacional Límite: Femenino / Humanos / Masculino / Recién Nacido Idioma: Inglés Revista: Chinese Medical Journal Año: 2015 Tipo del documento: Artículo