Distribution study of two constituents in rat after oral administration of Smilax china extract / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2512-2515, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-315410
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution in rat after oral administration of Smilax china extract.</p><p><b>METHOD</b>Oxyresveratrol and resveratrol were quantitatively determined by HPLC/DAD method in rat tissues including heart, liver, spleen, lung and kidney after oral administration of S. china extract. The separation was performed on a Zorbax SB-C18 column (4.6 mm x 250 mm, 5 microm) with acetonitrile-water using linear gradient elution and UV detection at wavelength of 320 nm. The flow rate was 1.0 mL x min(-1) and the column was kept at 40 degrees C.</p><p><b>RESULT</b>The HPLC/DAD method for the simultaneous determination of oxyresveratrol and resveratrol in rat tissues was developed.</p><p><b>CONCLUSION</b>The method has been successfully applied for the distribution study of two active constituents in rat through oral administration of S. china extract.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estilbenos
/
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Extractos Vegetales
/
Química
/
Administración Oral
/
Cromatografía Líquida de Alta Presión
/
Ratas Sprague-Dawley
/
Smilax
/
Evaluación Preclínica de Medicamentos
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Artículo
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