Optimization of solubilizing process of Qingkailing injection based on GA-BPNN modeling / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To optimize solubilizing process of Qingkailing injection.</p><p><b>METHOD</b>Uniform design experimental method and GA-BPNN modeling method were applied to optimize the technical parameters, and the solubility of cholic acid in medium was taken as optimizing index.</p><p><b>RESULT</b>The type of solubilizer and pH of medium had greater impact on the index than the concentration for solubilizer. The optimum solubilizer was Tween-80. In a certain range the higher pH of medium was optimum; it was not necessary to use high-concentration solubilizer although there was positive correlation between the index and the concentration of solubilizer.</p><p><b>CONCLUSION</b>Uniform design combined with GA-BPNN modeling method is suitable for optimization of solubilizing process of Chinese materia medica injection, which has certain practical application value.</p>