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Different glutamate receptor mechanisms in long-term depression induced by different stimulus patterns in the CA1 area of adult rat hippocampus / 生理学报
Acta Physiologica Sinica ; (6): 270-274, 2008.
Artículo en Inglés | WPRIM | ID: wpr-316730
ABSTRACT
Previous reports suggested that a novel stimulus pattern of multi-train stimulus at low-frequency (2-Hz or 5-Hz) could induce stable long-term depression (LTD) in the CA1 area of adult rat hippocampus. In the present study, in order to determine the mechanism in LTD induced by the two novel tetanus patterns, changes in the population spikes (PS) in the hippocampal CA1 area of adult rats following the multi-train stimulus in the presence of AP5 [antagonist of N-methyl-D-aspartate receptors (NMDARs)] or MCPG [antagonist of type I/II metabotropic glutamate receptors (mGluRs)] were recorded. The results showed that both AP5 and MCPG inhibited the LTD induced by 2-Hz multi-train stimulus. The mean amplitude of population spikes (PSA) normalized to the baseline was (96.0±3.5)% after applying AP5 (n=10) and (95.7±4.1)% after applying MCPG (n=8), respectively, measured at 20 min post-tetanus. While 5-Hz multi-train tetanus failed to induce LTD in the presence of MCPG. The mean PSA was (73.6±4.4)% (n=10) and (98.2±8.9)% (n=8) in the presence of AP5 and MCPG, respectively, measured at 35 min post-tetanus. So it is suggested that LTD induced by 2-Hz multi-train tetanus involves co-activation of NMDARs and mGluRs, while LTD induced by 5-Hz multi-train tetanus is only related to activation of mGluRs.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / 2-Amino-5-fosfonovalerato / Receptores de N-Metil-D-Aspartato / Receptores de Glutamato Metabotrópico / Depresión Sináptica a Largo Plazo / Región CA1 Hipocampal / Glicina Límite: Animales Idioma: Inglés Revista: Acta Physiologica Sinica Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / 2-Amino-5-fosfonovalerato / Receptores de N-Metil-D-Aspartato / Receptores de Glutamato Metabotrópico / Depresión Sináptica a Largo Plazo / Región CA1 Hipocampal / Glicina Límite: Animales Idioma: Inglés Revista: Acta Physiologica Sinica Año: 2008 Tipo del documento: Artículo