Effect of metformin on colorectal carcinoma in type 2 diabetes mellitus patients: a Markov model analysis / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 689-693, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-317567
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the colorectal cancer (CRC) prevention effect of metformin in comparison with that of other T2DM medications from a Markov model perspective.</p><p><b>METHODS</b>Literature concerning CRC morbidity of T2DM patients with metformin or other diabetes medications treatment was reviewed in PubMed and Cochrane Library database from September 2010 to December 2016.</p><p><b>INCLUSION CRITERIA</b>(1)enrolled population was adult patients with T2DM but without CRC; (2) any of the parameters applied in our model was reported; (3) randomized clinical trials (RCTs), quasi-randomized trials, prospective or retrospective cohort studies. With CRC morbidity as endpoint, parameters were extracted to construct Markov model to assess CRC morbidity and cumulative tumor-free survival in each group over 11 years' follow-up period. Finally, Monte Carlo analysis was performed to evaluate the influence of parameter instability on the model.</p><p><b>RESULTS</b>Seven literatures were recruited and 10 000 patients were virtually allocated for each arm. In contrast with non-metformin group, T2DM patients treated with metformin had a lower rate of CRC(1.670% vs. 2.146%, P=0.016). Moreover, cumulative tumor-free survival of metformin group was, slightly but significantly, better than that of non-metformin group (10.908 years vs. 10.882 years, P=0.000).</p><p><b>CONCLUSIONS</b>T2DM patients treated with metformin have a lower morbidity of CRC and a better cumulative tumor-free survival than those of non-metformin group. Large scale RCTs are needed to illustrate the role of metformin in the prevention of CRC.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Ensayo Clínico Controlado
/
Evaluación Económica en Salud
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Gastrointestinal Surgery
Año:
2017
Tipo del documento:
Artículo
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