Association between ABO blood groups and coronary heart disease in Chinese Guangxi Zhuang population / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 788-792, 2015.
Article
en Zh
| WPRIM
| ID: wpr-317689
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate this association between ABO blood groups and coronary heart disease (CHD) in the Chinese Guangxi Zhuang population.</p><p><b>METHODS</b>From August 2010 to April 2013, we performed a case-control study in a Chinese Zhuang population, which included 1 024 CHD cases and 1 024 age and gender-matched non-CHD controls. The ABO blood groups and biological variables were measured by standard laboratory procedures. The Gensini score was used to evaluate the severity of coronary artery stenosis.</p><p><b>RESULTS</b>Compared to non-CHD control group, CHD group had higher levels of fasting blood glucose ((6.71 ± 6.72) mmol/L vs. (4.98 ± 1.55) mmol/L, P < 0.001), LDL-C ((2.89 ± 1.18) mmol/L vs. (2.60 ± 1.05) mmol/L, P = 0.002) and CRP ((7.74 ± 7.32) mg/L vs. (2.93 ± 2.19)mg/L, P < 0.001) as well as higher proportion of history of hypertension (57.0% vs. 27.5%, P < 0.001), history of diabetes (29.6% vs. 9.6%, P < 0.001), family history of CHD (35.3% vs. 10.6%, P < 0.001) and smoking (51.0% vs. 38.2%, P < 0.001). Logistic analysis indicated that ABO blood groups were associated with CHD risk in the Chinese Zhuang population. Compared with group O, the group B individuals had a higher risk of CHD (OR = 2.33, 95% CI 1.88-2.90, P < 0.001), this result remained after adjustment for the conventional CHD risk factors (OR = 1.55, 95% CI 1.05-2.52, P = 0.047). In addition, there were significant differences of Gensini score between non-O subjects and group O subjects in the CHD group, and MACE at 1-year follow-up was similar between ABO blood groups of CHD individuals.</p><p><b>CONCLUSION</b>ABO blood groups are associated with CHD risk in the Chinese Zhuang population.</p>
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Asunto principal:
Sistema del Grupo Sanguíneo ABO
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Enfermedad de la Arteria Coronaria
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Fumar
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Estudios de Casos y Controles
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China
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Estenosis Coronaria
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Pueblo Asiatico
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Diabetes Mellitus
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Hipertensión
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Año:
2015
Tipo del documento:
Article