Establishment of a miniature pig model of mandibular osteoradionecrosis / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To establish a miniature pig model of mandibular osteoradionecrosis (ORN).</p><p><b>METHODS</b>A single dose of irradiation (IR25 Gy, 28 Gy) was delivered via an electronic linear accelerator to the right mandible of 24 miniature pigs by utilizing three dimensional conformal radiotherapy (3D-CRT). The first molar of the mandible was extracted 2 months after radiation. Mandibular ORN was diagnosed through gross observation, X-ray film, CT, and histopathologic examination.</p><p><b>RESULTS</b>At 3-4 months after radiation, all animals suffered from mandibular ORN after dental extraction. The symptoms of ORN were more severe in the 28 Gy group than in the 25 Gy group.</p><p><b>CONCLUSION</b>A miniature pig model of mandibular ORN can be established through 25 Gy irradiation + dental extraction.</p>