Outcome of kidney transplantation between controlled cardiac death and brain death donors: a meta-analysis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2829-2836, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-318527
ABSTRACT
<p><b>BACKGROUND</b>Our goal was to evaluate the outcomes of kidney transplants from controlled cardiac death donors compared with brain death donors by conducting a meta-analysis of cohort studies.</p><p><b>METHODS</b>The PubMed database and EMBASE were searched from January 1980 to July 2013 to identify studies that met pre-stated inclusion criteria. Reference lists of retrieved articles were also reviewed. Two authors independently extracted information on the designs of the studies, the characteristics of the study participants, and outcome assessments.</p><p><b>RESULTS</b>Nine cohort studies involving 84 398 participants were included in this meta-analysis; 3 014 received kidneys from controlled cardiac death donors and 80 684 from brain death donors. Warm ischemia time was significantly longer for the controlled cardiac death donor group. The incidence of delayed graft function was 2.74 times (P < 0.001) greater in the controlled cardiac death donor group. The results are in favor of the brain death donor group on short-term patient and graft survival while this difference became nonsignificant at mid-term and long term. Sensitivity analysis yielded similar results. No evidence of publication bias was observed.</p><p><b>CONCLUSION</b>This meta-analysis of retrospective cohort studies suggests that the outcome after controlled cardiac death donors is comparable with that obtained using kidneys from brain death donors.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Donantes de Tejidos
/
Muerte Encefálica
/
Estudios Retrospectivos
/
Trasplante de Riñón
/
Muerte
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2014
Tipo del documento:
Artículo
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