Synthesis and characterization of protocatechuic acid derivants / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 208-211, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-318691
ABSTRACT
To explore the effects of protocatechuic acid (PCA) and its derivants on angiogenesis of the chick embryo chorioallantoic membrane (CAM) and scavenging DPPH radical in vitro. The protection of benzyl and alkaline hydrolysis of benzyl ester were employed. The structures of PCA-1, PCA-2 and PCA-3, the derivates of PCA, were elucidated by 1H, 13C-NMR and MS data The bioactivity of PCA and its derivants was evaluated on the models of DPPH radical and chick embryo chorioallantoic membrane (CAM), respectively. PCA and PCA-1 showed the best activity of scavenging DPPH radical among all the compounds. In contrast to PCA-2, PCA and PCA-3 displayed inhibition to angiogenesis (P < 0.001). Pyrocatechol hydroxyl is the active site of PCA on scavenging DPPH radical in vitro. PCA with carboxyl and without pyrocatechol hydroxyl seems to show promotion to angiogenesis, but it needs more evidences.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Picratos
/
Compuestos de Bifenilo
/
Medicamentos Herbarios Chinos
/
Espectroscopía de Resonancia Magnética
/
Estructura Molecular
/
Catecoles
/
Química
/
Depuradores de Radicales Libres
/
Inductores de la Angiogénesis
/
Membrana Corioalantoides
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS