Study on solid dispersion of copovidone-based tanshinone II(A) / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 174-178, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-318697
ABSTRACT
<p><b>OBJECTIVE</b>To apply PVP-S630 in the preparation of tanshinone II(A) (TS II(A)) solid dispersion, in order to improve its dissolution in vitro and reduce the moisture absorption of the solid dispersion.</p><p><b>METHOD</b>Tanshinone II(A) solid dispersion was prepared by spray drying method. Such analytical methods as SEM, DSC, XRD were used to characterize their phases and detect their dissolution, moisture absorption and stability.</p><p><b>RESULT</b>In the solid dispersion prepared with tanshinone II(A) and copovidone with proportion of 110, tanshinone II(A) was scattered on the surface of the carrier in the amorphous form, with a dissolution in vitro up to 100% at 0.5 h and a lower moisture absorption than PVP-K30 solid dispersion prepared with the same proportion. After a three-month accelerated stability test, it showed no significant change in drug dissolution and content.</p><p><b>CONCLUSION</b>The solid dispersion prepared with copovidone as the carrier can significantly improve the dissolution of tanshinone II(A), with a relatively low moisture absorption and high stability, thereby having a good prospect of application.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pirrolidinas
/
Solubilidad
/
Factores de Tiempo
/
Compuestos de Vinilo
/
Rastreo Diferencial de Calorimetría
/
Portadores de Fármacos
/
Medicamentos Herbarios Chinos
/
Preparaciones Farmacéuticas
/
Agua
/
Disponibilidad Biológica
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2013
Tipo del documento:
Artículo
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