Effect of testosterone propionate on the distribution pattern of calcitonin gene-related peptide in different motoneuron pools / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 739-742, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-318825
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of testosterone propionate (TP) on the distribution pattern of calcitonin gene-related peptide (CGRP) in two types of motoneuron (Mn) pools in rats.</p><p><b>METHOD</b>The double labeling of cholera toxin B subunit coupled with colloidal gold (CB-Au) retrograde identification combining with immunocytochemistry was mainly used to reveal the distribution pattern of CGRP-like immunoreactivity (CGRP-LI) and its changes in the motoneuron pools labeled by CB-Au.</p><p><b>RESULT</b>TP injected intramuscularly 28 days later significantly decreased CGRP expression in Mn pool innervating extensor digitorum longus (EDL, fast-twitch), comparing with corresponding control and castration group respectively (P < 0.001), while no significant effect on Mn pools innervating soleus (SOL, slow-twitch, P > 0.05) was observed.</p><p><b>CONCLUSION</b>EDL-Mn pool is more sensitive to testosterone propionate than SOL-Mn pool in regulating CGRP expression.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Péptido Relacionado con Gen de Calcitonina
/
Ratas Wistar
/
Fibras Musculares de Contracción Lenta
/
Fibras Musculares de Contracción Rápida
/
Biología Celular
/
Propionato de Testosterona
/
Metabolismo
/
Neuronas Motoras
Límite:
Animales
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2005
Tipo del documento:
Artículo
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