Association between genetic polymorphisms in methylentetrahydrofolate reductase and risk of lung cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 700-703, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-318833
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between methylentetrahydrofolate reductase (MTHFR) polymorphisms and risk of lung cancer.</p><p><b>METHODS</b>Totally 505 cases with lung cancer and 500 frequency-matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism methods. The odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression model. Haplotype frequency was estimated using EH software.</p><p><b>RESULTS</b>The frequency of the MTHFR C677T allele in cases was significantly higher than that in controls (53.5% vs 44.9%, P < 0.001). Compared with the 677CC genotype, the 677CT and 677TT genotypes were associated with increased risk of lung cancer, with the OR being 1.43 (95% CI, 1.04-1.95) and 2.40 (95% CI, 1.61-3.59), respectively. In addition, a significant difference in the distribution of haplotype frequencies between cases and controls was observed.</p><p><b>CONCLUSION</b>Functional polymorphism in MTHFR is associated with increased risk of lung cancer in Chinese population.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Estudios de Casos y Controles
/
Riesgo
/
Predisposición Genética a la Enfermedad
/
Metilenotetrahidrofolato Reductasa (NADPH2)
/
Frecuencia de los Genes
/
Genética
/
Genotipo
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS