Clinical significance of the expression of MUC4 mRNA in peripheral blood mononuclear cells of pancreatic cancer patients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 624-627, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-318850
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression and clinical significance of MUC4 mRNA in peripheral blood mononuclear cells of pancreatic cancer patients.</p><p><b>METHODS</b>The expression of MUC4 mRNA in peripheral blood mononuclear cells of pancreatic cancer patients were detected with reverse transcription realtime PCR.</p><p><b>RESULTS</b>Expression of MUC4 mRNA was not detected in the peripheral blood mononuclear cells of chronic pancreatitis patients and normal healthy people, but was observed in those of pancreatic cancer patients. The positive expression rate of MUC4 mRNA in pancreatic cancer patients was 60%, which was significantly higher than those of chronic pancreatitis patients and normal healthy people (P < 0.01). The positive expression rate of MUC4 mRNA increased with the development of clinical stage, and the positive expression rate in stage of II - IV (TNM system) was 76.92%, which was significantly higher than that of I - II stage (P < 0.01).</p><p><b>CONCLUSIONS</b>Expression of MUC4 mRNA is highly correlated with the clinical stage in pancreatic cancer patients. Detecting the expression of MUC4 mRNA in peripheral blood mononuclear cells of pancreatic cancer patients may be helpful for the early diagnosis and differential diagnosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Pancreáticas
/
Patología
/
ARN Mensajero
/
Monocitos
/
Adenocarcinoma
/
Biomarcadores de Tumor
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Genética
/
Metabolismo
/
Mucinas
Tipo de estudio:
Estudio de tamizaje
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2005
Tipo del documento:
Artículo
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