Kappa-opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats / 生理学报
Acta Physiologica Sinica
;
(6): 91-95, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-318936
ABSTRACT
To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) on aorta in the rat, isolated aortic ring was perfused and the tension of the vessel was measured. It was shown (1) kappa-opioid receptor stimulation with U50,488H relaxed rat aorta dose-dependently; (2) the relaxation effect of U50,488H on aorta was partially endothelium-dependent; (3) the relaxation effect of U50,488H was significantly attenuated in the presence of glybenclamide and glipizide, two ATP-sensitive K(+) channel (K(ATP)) blockers; and (4) the relaxation effect of U50,488H on vessel bore no relationship to muscarinic-receptor, beta-adrenoceptor, prostaglandin and nitric oxide (NO). These results indicate that kappa-opioid receptor stimulation with U50,488H relaxes the aortic artery at least partially via K(ATP) channel in the rat.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aorta
/
Farmacología
/
Fisiología
/
Vasodilatación
/
Técnicas In Vitro
/
Ratas Sprague-Dawley
/
Receptores Opioides kappa
/
3,4-Dicloro-N-metil-N-(2-(1-pirrolidinil)-ciclohexil)-bencenacetamida, (trans)-Isómero
/
Canales KATP
/
Metabolismo
Límite:
Animales
Idioma:
Inglés
Revista:
Acta Physiologica Sinica
Año:
2003
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS