Effects of Mycobacterium tuberculosis infection on the transcriptional expression of human macrophage gene encoding ion channels and related regulatory elements / 生理学报
Acta Physiologica Sinica
;
(6): 14-18, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-318950
ABSTRACT
Expression microarray was employed in this study to investigate whether the ion channels and their regulatory elements encoding genes participate in the immune response to Mycobacterium tuberculosis infection. The results of a virulent strain were compared with those of the clinically isolated strains. The data demonstrate that K(+), Na(+), Ca(2+) and Cl(-) channels and their regulatory elements, such as the G protein, receptor and second messenger, protein kinase and protein phosphatase were involved in the immune reaction. The clinical strain affected more types of ion channels and respective regulatory elements. The data provides clues for further scrutiny into the role of ion channels and related elements in the interaction between Mycobacterium tuberculosis and host macrophage.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tuberculosis
/
Virulencia
/
Regulación de la Expresión Génica
/
Alergia e Inmunología
/
Elementos Reguladores de la Transcripción
/
Genética
/
Canales Iónicos
/
Macrófagos
/
Microbiología
/
Mycobacterium tuberculosis
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2003
Tipo del documento:
Artículo
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