Effects of total body irradiation injury on the participation of dermal fibroblasts in tissue repair / 生理学报
Acta Physiologica Sinica
;
(6): 395-399, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-318978
ABSTRACT
Wound combined with total body irradiation (TBI) injury results in impairment of tissue repair and delayed processes of healing, so it has been considered as an important and representative model of impaired wound healing, but the mechanism is not fully clarified. Fibroblasts in wound are the most important cells participating in tissue repair, whereas its radiosensitivity is not high. To understand whether TBI injury has direct damaging effects on fibroblasts in wound, fibroblasts in wound combined with TBI injury and in wound of simple incision injury were isolated and cultured, and parameters associated with tissue repair were determined. The results showed that the abilities of proliferation, attachment and adhesion of fibroblasts isolated from wounds combined with TBI injury significantly decreased as compared with those of simple incision injury, nevertheless, apoptotic ratio of fibroblasts isolated from wounds combined with TBI injury increased significantly. These data suggest that TBI injury may cause direct damaging effects on fibroblasts in wounds, which might be one of the dominant reasons for impairment of wound healing when it is combined with TBI injury.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Efectos de la Radiación
/
Traumatismos Experimentales por Radiación
/
Piel
/
Cicatrización de Heridas
/
Heridas y Lesiones
/
Irradiación Corporal Total
/
Ratas Wistar
/
Modelos Animales de Enfermedad
/
Fibroblastos
Límite:
Animales
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2002
Tipo del documento:
Artículo
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