The association between Fc gamma receptor IIA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 158-161, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-319030
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between Fc gamma receptor IIA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality.</p><p><b>METHODS</b>DNA samples were collected with buccal swabs from 63 patients with severe chronic periodontitis(CP), 103 patients with mild to moderate CP and 80 healthy individuals as control. Polymorphism in Fc gamma receptor IIA gene cluster was analyzed with PCR-SSP. The genotype distribution and allele frequency among different groups were compared.</p><p><b>RESULTS</b>It was found that the frequency of Fc gamma RIIA-R/R131 genotype was significantly higher in patients with severe CP (19.05%) compared to that of the healthy controls (P < 0.0125).</p><p><b>CONCLUSION</b>The Fc gamma RIIA-R/R131 genotype may be one of the contributors for the increased susceptibility to severe CP in Chinese Han nationality.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Periodontitis
/
Polimorfismo Genético
/
Antígenos CD
/
China
/
Reacción en Cadena de la Polimerasa
/
Enfermedad Crónica
/
Receptores de IgG
/
Predisposición Genética a la Enfermedad
/
Etnología
/
Frecuencia de los Genes
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2004
Tipo del documento:
Artículo
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