Detection of P-glycoprotein and glutathine S-transferase in mucoepidermoid carcinoma of salivary gland / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>The aim of this study was to investigate the mechanism(MDR) of multidrug resistance(MDR) of mucoepidermoid carcinoma in salivary gland.</p><p><b>METHODS</b>40 cases of mucoepidermoid carcinoma in salivary gland were examined the MDR gene product P-glycoprotein using a monoclonal antibody JSB-1. And 10 of them were also investigated by detecting the expression of GST-pi. All the cases had not been accepted any therapy before the samples were collected.</p><p><b>RESULTS</b>1. Positive expression of JSB-1 was observed in 27 of the 40 specimens. The positive expression was related not only with clinical stage, but also with differentiation degree. 2. The GST-pi positive expression was found in 9 of 10 cases. There was no significant different between the positive expression of JSB-1 and GST-pi.</p><p><b>CONCLUSION</b>JSB-1 and GST-pi play an important role in MDR of mucoepidermoid carcinoma.</p>