The expression of TGF-beta 1 mRNA in pubescent rhesus monkeys' condyle under Class III intermaxillary functional orthopedic force / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 73-76, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-319052
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of TGF-beta 1 mRNA in pubescent Rhesus monkeys' condylar under Class III intermaxillary functional orthopedic force for different lengths of time.</p><p><b>METHODS</b>Six pubescent Rhesus monkey were divided into two test groups and a control group. Monkeys in the test groups were TMAIII while the control groups did not. Histological method (HE staining) and in situ hybridization were employed in this study.</p><p><b>RESULTS</b>1. The histological results showed that, compared with the control group, the anterior part of the condyle became thicker while the median part and the posterior part became thinner in 3 months group. However, in 6 months group, the change was similar to 3 months group. 2. The results of in situ hybridization showed that, in control group, TGF-beta 1 mRNA mildly expressed in the anterior part of the condyle while extensively in the median and posterior parts. In 3 months group, TGF-beta 1 mRNA expressed in all parts of condyle; the most intensive expression was in the anterior part. Compared with 3 months group, the expression of TGF-beta 1 mRNA decreased in 6 months group, but the expression in anterior part was stronger than in median and posterior parts.</p><p><b>CONCLUSION</b>Under Class III Orthopedic therapy, TGF-beta 1 mRNA probably participated in the endochrondral bone remodeling in the condyle, and the expression was closely related to loading time. In 3 months group, the expression of TGF-beta 1 mRNA was stronger than that in 6 months group. It was inferred that the remodeling of endochrondral bone was more active in 3 months group.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
ARN Mensajero
/
Cartílago
/
Distribución Aleatoria
/
Expresión Génica
/
Factor de Crecimiento Transformador beta
/
Aparatos Ortodóncicos Funcionales
/
Factor de Crecimiento Transformador beta1
/
Genética
/
Macaca mulatta
Límite:
Animales
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2004
Tipo del documento:
Artículo
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