The effect of bFGF on proliferation of periodontal fibroblast-like cells of dogs / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 59-61, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-319056
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of basic fibroblast growth factor(bFGF) on proliferation of periodontal fibroblast-like cells in vivo.</p><p><b>METHODS</b>A U-shaped osseous defect was produced on the buccal side of the mesial root. Four posterior teeth were conducted in four quadrants. Each quadrant included 4 groups control, bFGF, expanded polytetrafluoroethylene(ePTFE) membrane, bFGF + ePTFE. Each time the 4 teeth sites in one quadrant were operated weekly and each dog experienced 4 times of operations. Bromodeoxyuridine(BrdU) was injected 1 hour prior to sacrificing the dogs at 4 weeks after first surgery. Immunohistochemical method was applied to count the BrdU-labeled fibroblast-like cells.</p><p><b>RESULTS</b>The number of BrdU-labeled cells reached the maximum at the 2nd week among all groups and then, decreased with time. Both bFGF and bFGF + ePTFE treated group had significantly more BrdU+ cells than remained control or ePTFE groups (P < 0.05) at 1st, 2nd weeks after surgery.</p><p><b>CONCLUSION</b>2 weeks after periodontal surgery is active phase of proliferation of periodontal fibroblasts. bFGF enhances fibroblast proliferation in early periodontal wound healing, and in turn accelerate periodontal regeneration.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Regeneración
/
Cirugía General
/
Cicatrización de Heridas
/
Periodoncio
/
División Celular
/
Factor 2 de Crecimiento de Fibroblastos
/
Biología Celular
/
Fibroblastos
Límite:
Animales
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2004
Tipo del documento:
Artículo
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