Effects of aminoguanidine on the expression of NOS in facial nerve and surrounding tissues of traumatic facial paralysis rats / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 7-9, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-319074
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of inducible NOS inhibitor aminoguanidine on the expression of NOS in facial nerve and surrounding tissue of traumatic facial paralysis rats.</p><p><b>METHODS</b>A small dose of aminoguanidine were intraperitoneally injected into rats before and after facial paralysis. The facial nerve and surrounding tissues were cut at different time point. Immunohistochemical ABC method was used to study the changes of NOS expression in facial nerve and surrounding tissues.</p><p><b>RESULTS</b>The inducible NOS immunoreactivity was obvious inhibited in the facial nerve and surrounding tissues in aminoguanidine group.</p><p><b>CONCLUSION</b>Aminoguanidine chronic treatment can obvious inhibit the inducible NOS expression in the facial nerve and surrounding tissues. Aminoguanidine can improve the regeneration of facial nerve and the recovery of traumatic tissues.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Distribución Aleatoria
/
Ratas Sprague-Dawley
/
Óxido Nítrico Sintasa
/
Traumatismos del Nervio Facial
/
Óxido Nítrico Sintasa de Tipo II
/
Nervio Facial
/
Parálisis Facial
/
Guanidinas
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2004
Tipo del documento:
Artículo
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