A novel class of testis-specific small RNAs: piRNAs / 中华男科学杂志
National Journal of Andrology
;
(12): 163-165, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-319271
ABSTRACT
Eukaryotes produce various types of 19-30 nt small RNAs, which act as guides to the regulation of gene expressions, such as mRNA degradation and translational repression. The Argonaute family members related to small RNA functions fall into 2 subfamilies. One is the AGO subfamily, whose 4 members distribute widely, confirmedly bind to miRNAs and siRNAs and inhibit the expression of target mRNAs through a pathway like RNA interference. The other is the PIWI subfamily, including PIWI, Aubgine (AUB) and AGO3, exclusively expressed in the testis. Recently, four research groups have isolated a new class of small RNAs from the mammalian testis, which interacts with the PIWI subfamily, hence named piwi-interfering RNAs (piRNAs), and is suggestive of an important role in spermatogenesis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Espermatogénesis
/
Testículo
/
Clasificación
/
MicroARNs
/
ARN Interferente Pequeño
/
Interferencia de ARN
/
Genética
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2008
Tipo del documento:
Artículo
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