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A novel class of testis-specific small RNAs: piRNAs / 中华男科学杂志
National Journal of Andrology ; (12): 163-165, 2008.
Artículo en Chino | WPRIM | ID: wpr-319271
ABSTRACT
Eukaryotes produce various types of 19-30 nt small RNAs, which act as guides to the regulation of gene expressions, such as mRNA degradation and translational repression. The Argonaute family members related to small RNA functions fall into 2 subfamilies. One is the AGO subfamily, whose 4 members distribute widely, confirmedly bind to miRNAs and siRNAs and inhibit the expression of target mRNAs through a pathway like RNA interference. The other is the PIWI subfamily, including PIWI, Aubgine (AUB) and AGO3, exclusively expressed in the testis. Recently, four research groups have isolated a new class of small RNAs from the mammalian testis, which interacts with the PIWI subfamily, hence named piwi-interfering RNAs (piRNAs), and is suggestive of an important role in spermatogenesis.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Espermatogénesis / Testículo / Clasificación / MicroARNs / ARN Interferente Pequeño / Interferencia de ARN / Genética / Metabolismo Límite: Animales Idioma: Chino Revista: National Journal of Andrology Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Espermatogénesis / Testículo / Clasificación / MicroARNs / ARN Interferente Pequeño / Interferencia de ARN / Genética / Metabolismo Límite: Animales Idioma: Chino Revista: National Journal of Andrology Año: 2008 Tipo del documento: Artículo