Cold stress induces the suppression of splenic NK cell activity and the c-fos expression in rat brain / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 313-316, 2002.
Article
en Zh
| WPRIM
| ID: wpr-319297
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To observe the effect of cold stress on the splenic NK cell activity and the c-fos expression in rat brain.</p><p><b>METHODS</b>Rats were maintained in cold chamber at 4 degrees for 4 h. The 51Cr release assay from YAC-1 cells was used to determine the splenic NK cell activity and the double staining of ABC method was employed to observe the immunoreactive expression of Fos, arginine-vasopressin and tyrosine hydroxylase.</p><p><b>RESULTS</b>Cold stress could induce a marked suppression of splenic NK cell activity and a significant expression of Fos protein in hypothalamic paraventricular nucleus(PVN), as well as in the brainstem locus coeruleus (LC). Double staining showed c-expression of Fos and arginine-vasopressin in some of PVN neurons, and co-expression of Fos and tyrosine hydroxylase in the majority of LC neurons.</p><p><b>CONCLUSION</b>The vasopressinergic neurons in PVN and the catecholaminergic neurons in LC might be probably involved in the suppression of splenic NK cell activity induced by cold stress.</p>
Texto completo:
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Índice:
WPRIM
Asunto principal:
Bazo
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Estrés Fisiológico
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Tirosina 3-Monooxigenasa
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Encéfalo
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Arginina Vasopresina
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Células Asesinas Naturales
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Proteínas Proto-Oncogénicas c-fos
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Ratas Wistar
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Frío
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Biología Celular
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Año:
2002
Tipo del documento:
Article