Relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents in cultured hypothalamic cells / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 30-33, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-319388
ABSTRACT
<p><b>AIM</b>To investigate the relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents.</p><p><b>METHODS</b>After hypoxic preconditioning and acute anoxia the I(Na), I(K) were measured in cultured hypothalamic cells by patch-clamp whole cell recording technique.</p><p><b>RESULTS</b>The amplification of Na+ currents did not been significantly changed, but the amplification of K+ currents was in hypoxic preconditioning neurons; acute anoxia lead to the inhibition of Na+, K+ currents in the two groups, while Na+, K+ currents in non-preconditioned control group were inhibited severity than hypoxic preconditioning group.</p><p><b>CONCLUSION</b>It is presumed enhanced anoxia tolerance induced by hypoxic preconditioning may be related to the opening of K+ channels.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxígeno
/
Fisiología
/
Potasio
/
Sodio
/
Hipoxia de la Célula
/
Células Cultivadas
/
Ratas Wistar
/
Técnicas de Placa-Clamp
/
Biología Celular
/
Hipotálamo
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2002
Tipo del documento:
Artículo
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