Preparation of baicalin colon-specific solid dispersion and evaluation on its in vitro release / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 71-74, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-319652
ABSTRACT
<p><b>OBJECTIVE</b>To prepare pH-dependent baicalin colon-specific solid dispersion, with the aim of colon-specific delivery and rapid drug release.</p><p><b>METHOD</b>Baicalin-eudragit S100 solid dispersion was prepared by using the solvent method. The microscopic structure and physicochemical properties were analyzed by using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and infrared spectroscopy (IR). And its in vitro release was also investigated.</p><p><b>RESULT</b>The results of DSC and XRD analysis suggested that baicalin may be dispersed in solid dispersion in the amorphous state. IR results indicated a non-covalent bond effect may exist between baicalin and eudragit S100. The results of in vitro release determination showed that very few baicalins in pH 1.2 diluted hydrochloric acid solution for 2 h at the baicalin-eudragit S100 ratio of 1 6. The accumulated dissolution rate was less than 15% in pH 6.8 phosphate buffer solution for 4 h, but exceeding 90% in pH 7.6 phosphate buffer solution for 1 h.</p><p><b>CONCLUSION</b>The prepared baicalin-eudragit S100 solid dispersion could achieve the objective of colon-specific delivery and rapid drug release, and helps increase the concentration of baicalin in colons.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ácidos Polimetacrílicos
/
Solubilidad
/
Solventes
/
Difracción de Rayos X
/
Flavonoides
/
Química
/
Colon
/
Concentración de Iones de Hidrógeno
/
Metabolismo
/
Métodos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2014
Tipo del documento:
Artículo
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