Role of voltage-sodium channels in neuropathic pain / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 217-221, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-319806
ABSTRACT
Voltage-gated sodium channels are critical for the generation and conduction of nerve impulses. Recent studies show that in primary sensory neurons, the expression and dynamic regulation of several sodium channel subtypes play important roles in neuropathic pain. A number of SCN9A (encoding Nav1.7) gene point mutations are related with human genetic pain disorders. Transgenic and specific knockout techniques have revealed that Nav1.3, Nav1.8, Nav1.9 are important for the development and maintenance of neuropathic pain condition. Specific blockers of these sodium channels have been demonstrated to be effective in alleviating allodynia and hyperalgesia. Here we reviewed the roles of sodium channels in neuropathic pain, which may be applicable for the development of new drugs with enhanced efficacy for neuropathic pain treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Canales de Sodio
/
Genética
/
Metabolismo
/
Neuralgia
/
Neuronas
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2011
Tipo del documento:
Artículo
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