Expression of vascular endothelial growth factor and microvessel density in hippocampus of rats with aging / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 404-408, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-319886
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in hippocampus of rats with aging.</p><p><b>METHODS</b>Paraffin sections of brain tissue of rats at the age of 3, 18, 24, 30 months were stained by immunohistochemistry, the expression of VEGF and MVD was quantitatively analyzed.</p><p><b>RESULTS</b>Innunohistochemical staining showed that the VEGF-positive cells were mainly pyramidal neuron in hippocampus; the intensity of VEGF-positivity in neuron cells was decreased with the aging (P<0.05). The MVD in hippocampus was also decreased with the aging of rats (P<0.05).</p><p><b>CONCLUSION</b>Increasing VEGF contents and improving blood circulation in brain tissue may prevent or treat vascular dementia and cerebrovascular diseases.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Envejecimiento
/
Capilares
/
Ratas Sprague-Dawley
/
Factor A de Crecimiento Endotelial Vascular
/
Genética
/
Hipocampo
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS