Association between CTLA-4 gene polymorphism and susceptibility to cervical cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 681-684, 2011.
Article
en Zh
| WPRIM
| ID: wpr-320107
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between CTLA-4 +49A/G polymorphisms and the risk of susceptibility to cervical cancer.</p><p><b>METHODS</b>A hospital-based case-control study was conducted. 314 cases with primary cervical cancer and 320 healthy controls were collected and genotyped by PCR-based RFLP for +49A/G polymorphisms in the CTLA-4 gene.</p><p><b>RESULTS</b>The A allele and AA genotype of CTLA-4 gene were 32.5% and 9.6% in the patients, and 25.8% and 5.6% in the controls, respectively. Subjects with CTLA-4 +49AA genotype conferred a higher risk of cervical cancer (OR = 2.06, 95%CI: 1.10 - 3.85; P = 0.024). However, the correlation between AA genotype in CTLA-4 polymorphisms and clinicopathological characteristics was not significant.</p><p><b>CONCLUSION</b>The results of this study suggest that CTLA4 gene is associated with cervical cancer risk and may be a susceptible gene of cervical cancer.</p>
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Índice:
WPRIM
Asunto principal:
Patología
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Polimorfismo Genético
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Cirugía General
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Polimorfismo de Longitud del Fragmento de Restricción
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Carcinoma in Situ
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Carcinoma de Células Escamosas
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Adenocarcinoma
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Estudios de Casos y Controles
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Neoplasias del Cuello Uterino
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Factores de Riesgo
Tipo de estudio:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Año:
2011
Tipo del documento:
Article