Clinical and prognostic significance of preoperative serum CA153, CEA and TPS levels in patients with primary breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 842-846, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-320125
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical and prognostic values of preoperative serum CA153, CEA and TPS levels in patients with primary breast cancer.</p><p><b>METHODS</b>A total of 386 hospitalized patients with stage I ∼ IV breast cancer from Nov 1998 to Feb 2009 were followed up, and their clinicopathological data were analyzed retrospectively to determine the factors affecting their prognosis.</p><p><b>RESULTS</b>First, preoperative serum CA153 expression level was significantly associated with the age of onset and tumor size (P < 0.05), the expression of serum CEA was correlated with tumor size (P < 0.05), and the expression of serum tissue polypeptide specific antigen (TPS) was correlated with tumor size and lymph node metastases (P < 0.05). Second, the overall survival was significantly shorter among patients with elevated serum CA153, CEA or TPS, respectively (P < 0.05 for overall). Finally, multivariate Cox regression analysis indicated that estrogen receptor status (ER) and elevated preoperative values of CA 153 are independent prognostic factors for overall survival (P < 0.05), and CA 153 is a risk factor but estrogen receptor status is a protective factor for overall survival.</p><p><b>CONCLUSIONS</b>Higher preoperative expression of serum CA153, CEA or TPS is closely correlated with clinicopathological characteristics and overall survival. The prognosis is poorer in primary breast cancer patients with higher CA15-3 expression level, and pre-treatment CA153 expression level can be used as an independent prognostic parameter in patients with primarily breast cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Péptidos
/
Pronóstico
/
Sangre
/
Neoplasias de la Mama
/
Antígeno Carcinoembrionario
/
Receptores de Estrógenos
/
Tasa de Supervivencia
/
Estudios Retrospectivos
/
Estudios de Seguimiento
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2011
Tipo del documento:
Artículo
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