Molecular genetics of functional articulation disorder in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 316-320, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-320655
ABSTRACT
Genetic factors are an important cause of functional articulation disorder in children. This article reviews some genes and chromosome regions associated with a genetic susceptibility to functional articulation disorders. The forkhead box P2 (FOXP2) gene on chromosome 7 is introduced in details including its structure, expression and function. The relationship between the FOXP2 gene and developmental apraxia of speech is discussed. As a transcription factor, FOXP2 gene regulates the expression of many genes. CNTNAP2 as an important target gene of FOXP2 is a key gene influencing language development. Functional articulation disorder may be developed to dyslexia, therefore some candidate regions and genes related to dyslexia, such as 3p12-13, 15q11-21, 6p22 and 1p34-36, are also introduced. ROBO1 gene in 3p12.3, ZNF280D gene, TCF12 gene, EKN1 gene in 15q21, and KIAA0319 gene in 6p22 have been candidate genes for the study of functional articulation disorder.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trastornos de la Articulación
/
Cromosomas Humanos Par 3
/
Cromosomas Humanos Par 6
/
Cromosomas Humanos Par 15
/
Predisposición Genética a la Enfermedad
/
Factores de Transcripción Forkhead
/
Genética
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2012
Tipo del documento:
Artículo
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