Changes in Synaptic Transmission and Long-term Potentiation Induction as a Possible Mechanism for Learning Disability in an Animal Model of Multiple Sclerosis / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: 26-32, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-32094
ABSTRACT
PURPOSE:
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. It has been shown that memory deficits is common in patients with MS. Recent studies using experimental autoimmune encephalomyelitis (EAE) as an animal model of MS have shown that indicated that EAE causes hippocampal-dependent impairment in learning and memory. Thus far, there have been no in vivo electrophysiological reports describing synaptic transmission in EAE animals. The aim of the present work is to evaluate the synaptic changes in the CA1 region of the hippocampus of EAE rats.METHODS:
To evaluate changes in synaptic transmission in the CA1 region of the hippocampus of EAE rats, field excitatory postsynaptic potentials (fEPSPs) from the stratum radiatum of CA1 neurons, were recorded following Schaffer collateral stimulation.RESULTS:
The results showed that EAE causes deficits in synaptic transmission and long-term potentiation (LTP) in the hippocampus. In addition, paired-pulse index with a 120 msec interstimulus interval was decreased in the EAE group. These findings indicate that EAE might induce suppression in synaptic transmission and LTP by increasing the inhibitory effect of GABAB receptors on the glutamate-mediated EPSP.CONCLUSIONS:
In conclusion, influence of inflammation-triggered mechanisms on synaptic transmission may explain the negative effect of EAE on learning abilities in rats.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sistema Nervioso Central
/
Enfermedades Desmielinizantes
/
Potenciación a Largo Plazo
/
Transmisión Sináptica
/
Potenciales Postsinápticos Excitadores
/
Modelos Animales
/
Encefalomielitis Autoinmune Experimental
/
Hipocampo
/
Aprendizaje
/
Discapacidades para el Aprendizaje
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
International Neurourology Journal
Año:
2016
Tipo del documento:
Artículo
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