Association between polymorphism of BDNF and internalizing disorders / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1265-1268, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-321073
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genetic association between brain-derived neurotrophic factor (BDNF) gene polymorphism and internalizing disorders, to provide the theoretical basis to explore the etiology of internalizing disorders.</p><p><b>METHODS</b>PCR-based ligase detection reaction (PCR-LDR) was applied to tag single nucleotide lengh polymorphism (SNPs) of BDNF gene among 259 undergraduates affected by internalizing disorders and 269 healthy undergraduates. Haplotype analysis and multiple locus analysis were conducted to analyze the genotyping data.</p><p><b>RESULTS</b>The genotypic frequency of tag SNPs of BDNF gene did not deviate from Hardy-Weinberg equilibrium in both case and control groups. Rs12273539 was not associated with internalizing disorders (P > 0.05), but rs10835210 and rs2030324 were related to internalizing disorders (P < 0.05). The case group had more A allele of rs10835210 and C allele of rs2030324 when compared to the controls while A allele of rs10835210 and C allele of rs2030324 seemed to be the risk factors of internalizing disorder (OR = 1.877, P < 0.001; OR = 1.347, P < 0.05). Results of multiple locus analysis showed that the haplotype composed by the three tag SNPs which was related to internalizing disorders (chi(2) = 23.537, P < 0.001).</p><p><b>CONCLUSION</b>BDNF gene might serve as the susceptible gene for internalizing disorder.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Haplotipos
/
Estudios de Casos y Controles
/
Factores de Riesgo
/
Factor Neurotrófico Derivado del Encéfalo
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Alelos
/
Frecuencia de los Genes
/
Genética
/
Genotipo
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2009
Tipo del documento:
Artículo
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