Polymorphism of short tandem repeat of exon 5 of MHC class-I chain related gene A and association with nasopharyngeal carcinoma in a southern Chinese population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 309-312, 2005.
Article
en Zh
| WPRIM
| ID: wpr-321098
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association between the short tandem repeat polymorphism of exon 5 of MICA gene (MICA-STR) and nasopharyngeal carcinoma (NPC) in a southern Chinese population.</p><p><b>METHODS</b>One hundred and twenty-seven consecutive NPC patients and 112 randomly selected normal controls residing in southern China mainland were analyzed for MICA-STR allelic variation and MICA gene deletion by fluorescent polymerase chain reaction-gene scanning and polymerase chain reaction-sequence specific priming.</p><p><b>RESULTS</b>MICA*A9 was observed at significantly higher frequency in the NPC patient group than in the control group (relative risk = 2.524, P = 0.001,Pc = 0.006); whereas MICA*A5.1 was present at significantly lower frequency in the NPC patient group than in the control group (RR = 0.418, P = 0.0004, Pc = 0.0026). Further analysis revealed that MICA*A9 was over-represented in male NPC patients, compared with male controls (RR = 3.23, P = 0.00095, Pc = 0.006); whereas MICA*A5.1 was present at significantly lower frequency in male NPC patients, compared with male controls (RR = 0.372, P = 0.0007, Pc = 0.004). None of the MICA-STR variants showed statistically significant frequency difference between female NPC patients and female controls (Pc > 0.05).</p><p><b>CONCLUSION</b>MICA-STR polymorphism is associated with NPC, and MICA*A9 is a genetic susceptibility marker of male individuals for NPC in a southern Chinese population.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Polimorfismo Genético
/
Antígenos de Histocompatibilidad Clase I
/
China
/
Neoplasias Nasofaríngeas
/
Reacción en Cadena de la Polimerasa
/
Exones
/
Repeticiones de Microsatélite
/
Predisposición Genética a la Enfermedad
/
Pueblo Asiatico
/
Etnología
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2005
Tipo del documento:
Article