Effects of cefodizime on chemokines of liver tissues in mice with immunological hepatic injury / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 746-750, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-321426
ABSTRACT
<p><b>BACKGROUND</b>Chronic hepatic inflammation is characterized by the accumulation of lymphocytes as a consequence of increased recruitment from the blood and retention within the tissue at sites of infection. CXC chemokine ligand 16 (CXCL16) mRNA has been detected in both inflamed and normal liver tissues and is strongly upregulated in the injured liver tissues in a murine model. The aim of this study was to investigate the effect of cefodizime on CXCL16 mRNA of liver tissues in mice with immunological hepatic injury.</p><p><b>METHODS</b>The murine model of immunological hepatic injury was induced by Bacillus Calmette Guerin and Lipoposaccharide. The mice with immunological hepatic injury were randomly assigned to the model group, the cefodizime group and the ceftriaxone group. The three groups were continuously given agents for seven days and CXCL16 mRNA of liver tissue was determined and contrasted with the control group treated by normal saline. Reverse transcription-polymerase chain reaction was used to assay CXCL16 mRNA levels in liver tissues.</p><p><b>RESULTS</b>The expressions of CXCL16 mRNA were significantly higher in the model group and the ceftriaxone group than in the control group and the cefodizime group (P < 0.05), indicating the mice in the model group and the ceftriaxone group were immunodeficient. There was no statistical difference in the expressions of CXCL16 mRNA between the control group and the cefodizime group. Similarly, no statistical difference in the expressions of CXCL16 mRNA between the model group and the ceftriaxone group was detected (P > 0.05).</p><p><b>CONCLUSION</b>Cefodizime effectively reduces the infiltration of lymphocytes into liver tissues and alleviates the liver damage by decreasing CXCL16 mRNA in liver tissues in mice with immunological hepatic injury.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
ARN Mensajero
/
Cefotaxima
/
Lipopolisacáridos
/
Quimiocinas
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Usos Terapéuticos
/
Toxicidad
/
Quimiocina CXCL6
/
Quimiocina CXCL16
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2011
Tipo del documento:
Artículo
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