Tactics used by HIV-1 to evade host innate, adaptive, and intrinsic immunities / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 2374-2379, 2013.
Article
en En
| WPRIM
| ID: wpr-322194
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To review the mechanisms by which HIV evades different components of the host immune system.</p><p><b>DATA SOURCES</b>This review is based on data obtained from published articles from 1991 to 2012. To perform the PubMed literature search, the following key words were input: HIV and immune evasion.</p><p><b>STUDY SELECTION</b>Articles containing information related to HIV immune evasion were selected.</p><p><b>RESULTS</b>Although HIV is able to induce vigorous antiviral immune responses, viral replication cannot be fully controlled, and neither pre-existing infected cells nor latent HIV infection can be completely eradicated. Like many other enveloped viruses, HIV can escape recognition by the innate and adaptive immune systems. Recent findings have demonstrated that HIV can also successfully evade host restriction factors, the components of intrinsic immune system, such as APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G), TRIM5α (tripartite motif 5-α), tetherin, and SAMHD1 (SAM-domain HD-domain containing protein).</p><p><b>CONCLUSIONS</b>HIV immune evasion plays an important role in HIV pathogenesis. Fully understanding the tactics deployed by HIV to evade various components of the host immune systems will allow for the development of novel strategies aimed toward the prevention and cure of HIV/AIDS.</p>
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Asunto principal:
Fisiología
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Proteínas del Sistema Complemento
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Células Asesinas Naturales
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Proteínas Portadoras
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Antígenos CD
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VIH-1
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Proteínas de Unión al GTP Monoméricas
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Citidina Desaminasa
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Alergia e Inmunología
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Anticuerpos Neutralizantes
Límite:
Humans
Idioma:
En
Revista:
Chinese Medical Journal
Año:
2013
Tipo del documento:
Article