Study of sexual hormone changes in prostate cancer patients before and after androgen deprivation therapy / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVES</b>To investigate and observe serum sexual hormone (testosterone, T; free testosterone, FT; dihydrotestosterone, DHT) changes in patients with prostate cancer (PCa) before and after androgen deprivation.</p><p><b>METHODS</b>Serum T, FT, DHT were measured with radioimmunoassay in 16 cases with PCa respectively one week before and the fifth day after androgen deprivation. The changes of T, FT, DHT were analyzed.</p><p><b>RESULTS</b>Serum T, FT, DHT declined 92.27%, 92.26%, 58.36% respectively. They were statistically significant before and after androgen deprivation (P < 0.001).</p><p><b>CONCLUSIONS</b>After androgen deprivation, most T and FT were deprived while DHT declined 58.36% only. Androgen receptor competitor shall be applied continually to prohibit the action of remnant androgen.</p>