Changes of 5 alpha-reductase type II activity in sexual gland of diabetic male rats / 中华男科学杂志
National Journal of Andrology
;
(12): 82-84, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-322544
ABSTRACT
<p><b>OBJECTIVES</b>To study the changes of sexual gland 5 alpha-reductase type II activity in pubertal and adult rats with diabetes.</p><p><b>METHODS</b>We selected 40 and 90 days old male Wistar rats as pubertal and adult animal model respectively, 30 rats in each group. The rats were randomly divided into three groups control group (C), diabetic group (D) and diabetes with insulin replacement group (ID). The activity of 5 alpha-reductase type II was measured with thin layer chromatography in the epididymis, prostate and testis.</p><p><b>RESULTS</b>1. In all sexual glands of pubertal rats, the activity of 5 alpha-reductase type II in D group is significantly lower than that in C and ID groups. 2. In all sexual glands of adult rats. there is no difference in the activity of 5 alpha-reductase type II among these groups.</p><p><b>CONCLUSIONS</b>The activity of 5 alpha-reductase type II is likely to be influenced by metabolic environment, hormonal levels and local specific factors in pubertal rats, but it is relatively stable in adult rats.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Próstata
/
Testículo
/
3-Oxo-5-alfa-Esteroide 4-Deshidrogenasa
/
Ratas Wistar
/
Diabetes Mellitus Experimental
/
Epidídimo
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2003
Tipo del documento:
Artículo
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