Inhibition of tonic contraction of smooth muscle: a new approach to achieve erection dysfunction / 中华男科学杂志
National Journal of Andrology
;
(12): 391-394, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-322584
ABSTRACT
It has shown that vasoconstriction in the cavernosal circulation is mediated by the RhoA/Rho-kinase calcium sensitization pathway. Inhibition of Rho-kinase activity in cavernosal smooth muscle with Y-27632 resulted in an erectile response marked by elevated intracavernosal pressure (ICP) without a significant change in men arterial pressure (MAP). To explain how erection can occurred in the presence of this strong vasoconstrictive signal, we have hypothesized that nitric oxide (NO) induces vasodilation leading to erection by directly inhibiting activity of the RhoA/Rho-kinase pathway, thereby reducing vasoconstriction. Administration of Y-27632 restored erectile function in rat models of hypogonadism and hypertension, suggesting that Rho-kinase inhibition may have potential clinical value. In addition, our results show that topical application of Y-27632 may be an effective mode of treatment for erectile dysfunction.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Piridinas
/
Erección Peniana
/
Proteínas Serina-Treonina Quinasas
/
Proteína de Unión al GTP rhoA
/
Péptidos y Proteínas de Señalización Intracelular
/
Modelos Animales de Enfermedad
/
Quinasas Asociadas a rho
/
Amidas
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2002
Tipo del documento:
Artículo
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