Effects of gap junction blocking on the oxygen partial pressure in acupoints of the bladder meridian / 中国针灸
Chinese Acupuncture & Moxibustion
;
(12): 1011-1014, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-322691
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relation between gap junction and meridian phenomenon.</p><p><b>METHODS</b>The oxygen partial pressure in acupoints [see text for formula] and in their corresponding non-acupoints of the Bladder Meridian was observed with the needle-type tissue oxygen tension sensor in the gap junction blocking goats by 1-Heptanol injection and the Connexin 43 (Cx43) gene knockout mice.</p><p><b>RESULTS</b>(1) The oxygen partial pressure in acupoints of Bladder Meridian on goats was higher than that in non-acupoints after 1-Heptanol injection with significant differences between them (both P < 0.01). (2) The oxygen partial pressure in acupoints of Bladder Meridian on goats increased significantly after injecting 1-Heptanol as compare with that either injecting normal saline or injecting nothing with significant differences between them (all P < 0.01). (3) The oxygen partial pressure in acupoints of the Bladder Meridian was significantly higher than that in the non-acupoint controls in Cx43 wild type (WT) mice (all P < 0.01). In Cx43 heterozygote (HT) mice, the oxygen partial pressure between acupoints and non-acupoint controls showed no significant differences (all P > 0.05). (4) In acupoints, the oxygen partial pressure in Cx43 WT mice was significantly higher than that in Cx43 HT mice (all P < 0.05), while in the corresponding non-acupoints, this difference had no statistically significant (all P > 0.05).</p><p><b>CONCLUSION</b>Gap junction maybe the essential factor in signal transduction of acupuncture.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxígeno
/
Presión Parcial
/
Vejiga Urinaria
/
Cabras
/
Puntos de Acupuntura
/
Química
/
Meridianos
/
Ratones Noqueados
/
Uniones Comunicantes
/
Conexina 43
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Acupuncture & Moxibustion
Año:
2010
Tipo del documento:
Artículo
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