Identification of gene-gene interactions related to the etiology of complex disease: a multifactor dimensionality reduction-genotype pedigree disequilibrium test / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1036-1040, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-322845
ABSTRACT
<p><b>UNLABELLED</b>To introduce the application of a multifactor dimensionality reduction-genotype pedigree disequilibrium test (MDR-PDT) for detecting gene-gene interactions in the etiology of complex disease. A brief overview on the basic theory, implementing steps and features of MDR-PDT were described, and a practical research case was demonstrated to application of MDR-PDT in nuclear family studies. The MDR-PDT approach was the extension or development of conventional MDR method which could be used for detecting gene-gene interactions in families of diverse structure.</p><p><b>CONCLUSION</b>MDR-PDT was a new nonparametric and model-free method which might use additional family members in the nuclear families and had a good power to identify gene-gene interactions.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Linaje
/
Desequilibrio de Ligamiento
/
Estadísticas no Paramétricas
/
Predisposición Genética a la Enfermedad
/
Epistasis Genética
/
Genotipo
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2007
Tipo del documento:
Artículo
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