Synthesis of diethylenetriamine polydentate ligands and their DNA-cleaving activity / 药学学报
Acta Pharmaceutica Sinica
;
(12): 380-384, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-323032
ABSTRACT
A series of multinuclear diethylenetriamine ligands were synthesized and used as artificial nuclease enzyme model. Target compounds were characterized by 1H NMR, 13C NMR, IR and ESI-MS. Preliminary studies on the cleavage of pUC19 DNA in the presence of metal complexes have also been performed and the results revealed that these complexes could act as powerful catalysts for the cleavage of pUC19 DNA after 48 h under physiological conditions. The hydrolytic cleavage mechanism of DNA plasmid by title compound was confirmed by T4 DNA ligase experiment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Poliaminas
/
Espectrofotometría Infrarroja
/
ADN
/
Espectroscopía de Resonancia Magnética
/
Química
/
Espectrometría de Masa por Ionización de Electrospray
/
División del ADN
/
Ligandos
/
Metabolismo
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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