Chemical approaches for trapping protein thiols and their oxidative modification / 药学学报
Acta Pharmaceutica Sinica
;
(12): 280-290, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-323045
ABSTRACT
Redox signal transduction, especially the oxidative modification of proein thiols, correlates with many diseases and becomes an expanding research area. However, there was rare method for quick and specific detection of protein thiols and their oxidative modification in living cells. In this article, we review the current chemical strategies for the detection and quantification of protein thiols and related cysteine oxidation. We also look into the future of the development of fluorescent probes for protein thiols and their potential application in the research of reactive cysteine proteomes and early detection of redox-related diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxidación-Reducción
/
Ácidos Sulfénicos
/
Compuestos de Sulfhidrilo
/
Proteínas
/
Nitrosación
/
Química
/
Especies Reactivas de Oxígeno
/
Cisteína
/
Especies de Nitrógeno Reactivo
/
Colorantes Fluorescentes
Tipo de estudio:
Estudio de tamizaje
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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