Coumarins of Anemone raddeana Regel and their biological activity / 药学学报
Acta Pharmaceutica Sinica
; (12): 206-209, 2012.
Article
en Zh
| WPRIM
| ID: wpr-323057
Biblioteca responsable:
WPRO
ABSTRACT
To study the coumarins of Anemone raddeana Regel, the compounds were separated by silica gel column chromatography and HPLC. Their structures were identified by their physicochemical property and spectral analysis. Two new compounds were isolated and identified as 4, 7-dimethoxyl-5-methyl-6-hydroxy coumarin (1) and 4, 7-dimethoxyl-5-formyl-6-hydroxycoumarin (2). The bioassays indicated that compounds 1 and 2 could significantly inhibit the proliferation of cancer cell, and showed the agonist effect on the transactivity of retinoic acid receptor-alpha (RARalpha). In addition, the two compounds had inhibitory effect against human leukocyte elastase (HLE).
Texto completo:
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Índice:
WPRIM
Asunto principal:
Farmacología
/
Plantas Medicinales
/
Estructura Molecular
/
Activación Transcripcional
/
Química
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Receptores de Ácido Retinoico
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Elastasa de Leucocito
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Concentración 50 Inhibidora
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Cumarinas
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Rizoma
Límite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Article