Research progress of the selective sphingosine-1-phosphate receptor 1 agonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 7-17, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-323087
ABSTRACT
Sphingosine-1-phosphate (S1P) is a lysophospholipid signaling molecule that regulates important biological functions in both intracellular and extracellular compartments. It interacts with five G protein-coupled receptors subtypes (S1PR(1-5)) to generate multiple downstream signaling. Activation of S1PR1 has been validated to be involved in the process of immune modulation. Fingolimod (FTY720), the novel S1PR1 agonist, has been approved for the treatment of multiple sclerosis in clinical trials. The study towards discovery of selective S1PR1 agonists has become hot spot for immunological diseases. This article summarized the research progress of S1PR1 agonists, emphasizing their structure types, structure-activity relationship and direction of development.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Glicoles de Propileno
/
Esfingosina
/
Relación Estructura-Actividad
/
Lisofosfolípidos
/
Clasificación
/
Usos Terapéuticos
/
Receptores de Lisoesfingolípidos
/
Quimioterapia
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2012
Tipo del documento:
Artículo
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