Synthesis of seven sinapine analogs and their effects on the tension of smooth muscle of intestines isolated from rabbit / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1466-1470, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-323100
ABSTRACT
Seven sinapine analogs (6a-6g) were synthesized using cinnamon acid or benzoic acid and their derivatives as starting materials, which obtained from substituted benzaldehyde and malonate. The structures of target compounds were characterized by IR, 1H NMR and elemental analysis. The effects of compounds 6a-6g on the smooth muscle of intestine isolated from rabbit were studied, and the experimental results showed that compounds 6a, 6d and 6g had diastolic action, while 6f had contractile action.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Técnicas In Vitro
/
Estructura Molecular
/
Química
/
Colina
/
Intestinos
/
Contracción Muscular
/
Músculo Liso
/
Tono Muscular
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
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