Expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance / 中华男科学杂志
National Journal of Andrology
;
(12): 511-513, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-323321
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance.</p><p><b>METHODS</b>RT-PCR method was used to examine the expression of TGF-beta1 mRNA in normal and carcinomatous prostate tissues.</p><p><b>RESULTS</b>The relative content of TGF-beta1 mRNA of normal prostate tissues was (0.74 +/- 0.11), while those of carcinomatous prostate tissues at T1-T2 and T3-T4 stages were (0.69 +/- 0.10) and (0.44 +/- 0.08) respectively, with significant difference between T1-T2 and T3-T4 (P < 0.05). And the relative contents of TGF-beta1 mRNA of carcinomatous prostate tissues with Gleason score < or = 5, 6-8 and > or = 9 were (0.70 +/- 0.12), (0.54 +/- 0.11) and (0.42 +/- 0.09) respectively.</p><p><b>CONCLUSION</b>The expression of TGF-beta1 mRNA was negatively correlated with the clinical stage and Gleason score of prostate carcinoma.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias de la Próstata
/
ARN Mensajero
/
Factor de Crecimiento Transformador beta
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Genética
/
Metabolismo
/
Estadificación de Neoplasias
Límite:
Anciano
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS