B-type natriuretic peptides and subclinical target organ damage in essential hypertensive patients / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between B-type natriuretic peptides (BNP) and subclinical target organ damage in essential hypertensive (EH) patients.</p><p><b>METHODS</b>A total of 317 EH patients were divided into 3 groups according to BNP levels, namely normal (BNP<600 ng/L) group (n=102), moderate (600-883.5 ng/L) group (n=116), and elevated BNP (>883.5 ng/L) group (n=99). The blood pressure, left ventricular mass index (LVMI), the intima media thickness (IMT) of the common carotid artery, the plaque size in the coronary artery (CS) and microalbuminuria levels were analyzed in these patients.</p><p><b>RESULTS</b>The EH patients with moderate and elevated BNP showed significantly higher LVMI, IMT, CS and microalbuminuria levels than those with normal BNP level (LVMI 102.8∓23.12 and 123.9∓26.47 vs 91.09∓18.71 g/m2; IMT 0.95∓0.32 and 1.16∓0.37 vs 0.84∓0.28 mm; microalbuminuria 31.36∓20.55 and 36.73∓22.07 vs 23.21∓18.68, P<0.01). After adjustment, BNP was positively correlated to LVMI, IMT, CS and microalbuminuria level (r=0.45, 0.43, 0.39 and 0.41, respectively, P<0.01). Multivariate logistic regression analysis showed that age, systolic blood pressure, BNP, FPG, and microalbuminuria, LDL-C, and BMI were all related to the occurrence of subclinical target organ damages.</p><p><b>CONCLUSION</b>BNP is positively correlated to subclinical target organs damages in EH patients.</p>