Exercise-induced changes of T lymphocytes subgroups and immune factors / 南方医科大学学报
Journal of Southern Medical University
; (12): 2277-2280, 2010.
Article
en Zh
| WPRIM
| ID: wpr-323683
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes in white blood cell populations, lymphocyte subsets and stress-related cytokines after long-term exercise training and address the association between blood cell changes and stress-related cytokines in relation to exercise.</p><p><b>METHODS</b>A total of 1038 professional athletes were examined for CBC with Sysmex XE2100, and the T, B, and NK lymphocyte subsets were analyzed with flow cytometry. The testees' RNA were extracted from 1 ml whole blood, and the stress-related cytokines such as CRP, SELL,TNF-α, IL8, IL4, ICAM1, PECAM1, IL6, and NOS were tested by multi-RT-PCR and fragments separated by capillary electrophoresis using Beckman Coulter GeXP system.</p><p><b>RESULTS</b>No obvious difference was found in WBC count between the athletes, all within normal range. The proportion of lymphocytes was increased in the athletes by 20%-40% in comparison with the normal level, and the CD3+, CD3+CD4+, and CD3+CD8+ T, B, and NK lymphocyte subsets were all lower in the athletes than the normal range. The cytokine expressions exhibited no significant gender-related difference. IL-8, TNF-α and SELL expressions increased while IL-4 decreased in the athletes. Correlations were noted between the changes of the cells and the cytokine expressions.</p><p><b>CONCLUSION</b>Long-term exercise training affects the immune system and cause stress, which may potentially increase the risks of some chronic diseases.</p>
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Asunto principal:
Fisiología
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Estrés Fisiológico
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Ejercicio Físico
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Citocinas
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Subgrupos Linfocitarios
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Recuento de Linfocitos
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Biología Celular
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Alergia e Inmunología
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Atletas
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Citometría de Flujo
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2010
Tipo del documento:
Article