A Case of Allergic Contact Dermatitis Due to Sodium Sulfite Contained in Nizoral(R) Cream / 대한피부과학회지

ABSTRACT

Sodium sulfite is an antioxidant, a preservative and a reducing agent, widely used in the foods, beverages, drugs, cosmetics, and pharmaceutical industries. Oral ingestion or inhalation of it in asthmatic patients may provoke asthmatic attack, urticaria, angioedema, and anaphylaxis. A 28-year-old male presented with well-demarcated erythematous scaly patch with itching sensation on the left lower leg. He had applied Nizoral(R) cream on the erythematous patch of the left lower leg for 7 days and the skin lesion was aggravated. Patch tests with Nizoral(R) cream 'as is' showed positive reaction and sodium sulfite, the ingredient of Nizoral cream, revealed positive reaction.